UPREGULATION OF NEUROGLOBIN PROMOTES TM3 LEYDIG CELL VIABILITY
نویسندگان
چکیده
منابع مشابه
The actions of calcitonin on the TM3 Leydig cell line and on rat Leydig cell-enriched cultures.
Studies demonstrating calcitonin receptors on Leydig cells have suggested that these cells may be one of the many sites affected by this peptide. To investigate this possibility, the effect of synthetic salmon calcitonin on the TM3 Leydig cell line (derived from immature mouse Leydig cells) and on primary Leydig cell-enriched preparations was examined. Synthetic salmon calcitonin stimulated the...
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OBJECTIVE To investigate whether nicotine-induced testicular toxicity involves the induction of apoptosis in Leydig cells. DESIGN Cell study using cells of the TM3 cell line derived from mouse Leydig cells. SETTING Academic research laboratory. INTERVENTION(S) Morphological and biochemical analyses for the detection of apoptosis. MAIN OUTCOME MEASURE(S) The effect of nicotine on the occ...
متن کاملCox7a2 mediates steroidogenesis in TM3 mouse Leydig cells.
AIM To investigate the regulatory function of Cox7a2 on steroidogenesis and the mechanism involved in TM3 mouse Leydig cells. METHODS The cDNA of Cox7a2 was cloned from TM3 mouse Leydig cells. It was subcloned to pDsRed-Express-N1 and transfected back into TM3 mouse Leydig cells for Cox7a2 overexpression by transient gene transfection. Steroidogenesis affected by overexpressed Cox7a2 was stud...
متن کاملInsights into GABA receptor signalling in TM3 Leydig cells.
Gamma-aminobutyric acid (GABA) is an emerging signalling molecule in endocrine organs, since it is produced by endocrine cells and acts via GABA(A) receptors in a paracrine/autocrine fashion. Testicular Leydig cells are producers and targets for GABA. These cells express GABA(A) receptor subunits and in the murine Leydig cell line TM3 pharmacological activation leads to increased proliferation....
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The neurotransmitter gamma-aminobutyric acid (GABA) and subtypes of GABA receptors were recently identified in adult testes. Since adult Leydig cells possess both the GABA biosynthetic enzyme glutamate decarboxylase (GAD), as well as GABA(A) and GABA(B) receptors, it is possible that GABA may act as auto-/paracrine molecule to regulate Leydig cell function. The present study was aimed to examin...
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ژورنال
عنوان ژورنال: Trakya University Journal of Natural Sciences
سال: 2018
ISSN: 2147-0294
DOI: 10.23902/trkjnat.393371